| 1,661 | 39 | 42 |
| 下载次数 | 被引频次 | 阅读次数 |
白细胞介素-6(IL-6)作为一种重要的炎性因子参与了多种炎症、免疫反应过程,并在肿瘤的发生、发展中起着重要作用。IL-6与其受体结合激活相关信号通路,如Janus蛋白酪氨酸蛋白激酶2(JAK2)、信号转导和转录激活因子3(STAT3)信号通路,Ras蛋白、细胞外信号调节激酶(ERK)及丝裂原活化蛋白激酶(MAPK)信号通路,以及磷脂酰肌醇3-激酶(PI3K)、蛋白激酶B(AKT)信号通路。肿瘤细胞中IL-6通过多条信号通路参与肿瘤细胞增殖、分化、侵袭、转移和血管增生等过程,抑制IL-6及其信号通路是肿瘤治疗的研究方向。IL-6不是单独在机体中发挥作用,与其他细胞因子协同对肿瘤的发生和影响可能更大,联合检测多种细胞因子指标对肿瘤发展程度的判断更为客观。
Abstract：Interleukin-6(IL-6),as an important inflammatory factor,is involved in a variety of inflammatory and the process of immune responses.It also plays an important role in the occurrence and development of tumors.IL-6 combines with its receptor,which in turn activates relevant signaling pathways,such as the signal pathway of Janus kinase(JAK2) and signal transduction and activator of transcription 3(STAT3),the signal pathway of Ras protein/extracellular regulated protein kinases/mitogen-activated protein kinase(Ras/ERK/MAPK) and the signal pathway of phosphatidylinositol 3 kinase/AKT(PI3 K/AKT).In tumor cells,IL-6 is involved in cell proliferation,differentiation,invasion,metastasis and angiogenesis and others through multiple signaling pathways.Inhibitions of IL-6 and its signaling pathway are a research focus in tumor therapy.IL-6 doesn't play the role alone in human body,and it is more possible that IL-6 cooperates with other cytokines on the occurrence and effect of tumor.In tumor cells,-6 is involved in cell proliferation,differentiation,invasion,metastasis and angiogenesis through multiple signaling pathways.It is more objective to judge the degree of tumor development by measuring multiple cytokines together.
[1]成军.现代细胞凋亡分子生物学[M].2版.北京:科学出版社,2012.
[2]Taniguchi K,Karin M.IL-6 and related cytokines as the critical lynchpins between inflammation and cancer[J].Semin Immunol,2014,26(1):54-74.
[3]Lippitz BE.Cytokine patterns in patients with cancer:A systematic review J].Lancet Oncol,2013,14(6):218-228.
[4]Hodge DR,Hurt EM,Farrar WL.The role of IL-6 and STAT3 in inflammation and cancer[J].Eur J Cancer,2005,41(16):2502-2512.
[5]Chen MF,Lin PY,Wu CF,et al.IL-6expression regulates tumorigenicity and corelates with prognosis in bladder cancer[J].PLo S One,2013,8(4):e61901.
[6]孙祖俊,罗清琼,陈福祥.TLR4介导口腔鳞癌细胞分泌IL-6、IL-8及VEGF[J].现代免疫学,2010,30,395-398.
[7]He G,Dhar D,Nakagawa H.Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling[J].Cell,2013,155(2):384-396.
[8]Yeh KY,Wu TH,Wu TL.Colorectal cancer cellderivedinterleukin-6enhances the phagocytic capacity andmigrationof THP-1 cells[J].Cytokine,2016,79:82-89.
[9]Pasquier J,Gosset M,Geyl C,et al.CCL2/CCL5secreted by the stroma induce IL-6/PYK2dependent chemoresistance in ovarian cancer[J].Mol Cancer,2018,17(1):47.
[10]张雅,刘晓红,李艳川,等.血清IL-6、mi R-17-5p水平与卵巢癌患者化疗后生存期的相关性分析[J].现代生物医学进展,2017,17(28):5540-5547.
[11]Park GB,Jeong JY,Kim D.Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1signaling[J].Oncol Lett,2017,14(6):7947-7956.
[12]陈亮,盛修贵.IL-6/STAT3信号通路与卵巢癌关系研究进展[J].中华肿瘤防治杂志,2015,22(15):1253-1256.
[13]方艳惠,赵喜娃,安丽沙.IL-6对卵巢癌细胞迁移和侵袭影响及机制探讨[J].中华肿瘤防治杂志,2018,25(16):1156-1162.
[14]徐法东,刘庆来,王金申.IL-4和IL-6在胃癌组织中的表达水平及临床意义[J].中国现代普通外科进展,2016,19(6):451-454.
[15]董旭.IL-6、IL-26在胃癌患者中的变化及其临床意义[J].国际检验医学杂志,2018,39(9):1095-1097,1101.
[16]郭佳.血清IL-6、CRP、CA19-9和CEA在胃癌患者中的检测意义[J].湖南师范大学学报(医学版),2016,13(5):63-66.
[17]单洪丽.IL-6-STAT3信号通路调控铁调素水平对胃癌细胞增殖及转移的研究[D].长春:吉林大学,2017.
[18]熊书君.肝癌患者血清趋化因子12和IL-6水平与其转移复发的关系[J].实用癌症杂志,2017,32(1):27-29.
[19]Schmidt-Arras D,Rose-John S.IL-6 pathway in the liver:From physiopathology to therapy[J].J Hepatol,2016,64(6):1403-1415.
[20]叶明.原发性肝癌患者血清IL-6、IL-18和IL-18BP检测的意义[J].实用肝脏病杂志,2016,19(3):354-355.
[21]徐晓林,丁建民,高英堂,等.外周血IL-6对早期肝癌微波消融后复发的预测[J].介入放射学杂志,2017,26(3):232-236.
[22]Choi SS,Diehl AM.Epielial-to-Mesenchymal Transitions in the Live[J].Hepatology,2009,50(6):2007-2013.
[23]周彤.IL-6/STAT3/SNAIL信号通路介导的上皮间质转化在肝癌射频消融后复发中的作用机制研究[D].济南:山东大学,2017.
[24]于涛,徐岩岩,宫婷,等.白细胞介素-6/信号转导和转录激活因子3信号通路在大细胞肺癌NL9980细胞系增殖中的作用及机制[J].中国癌症杂志,2017,27(10):770-774.
[25]Wang L,Cao L,Wang H,et al.Cancerassociated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway[J].Oncotarget,2017,8(44):76116-76128.
[26]李静,代婀娜,许良.鸦胆子油乳对Lewis肺癌小鼠恶病质相关细胞因子TNF-α/IL-6的影响[J].中华肿瘤防治杂志,2017,24(18):1280-1283.
[27]戴春,周永春,黄云超,等.非小细胞肺癌患者血清中细胞因子(IL-2、IL-4、IL-6、IL-10)的含量与临床分期的关系[J].现代肿瘤医学,2015,23(6):779-781.
[28]高伟,赵晓霞,郭绪晓.肺癌患者血清IL-6、IL-8及TNF-α的表达及临床意义[J].河北医药,2012,34(4):487-488.
[29]Ni M,Liu X,Wu J,et al.Identification of Candidate Biomarkers Correlated With the Pathogenesis and Prognosis of Non-small Cell Lung Cancer via Integrated Bioinformatics Analysis[J].Front Genet,2018(9):1-14.
[30]陈静静,门万琪,成祖群,等.结肠癌患者血清IL-6、CEA和CA19-9联合检测的临床意义[J].免疫学杂志,2013,29(12):1071-1073.
[31]任春贞,骆亚莉,刘永琦,等.IL-6和TNF-α模拟炎性微环境促进人BMSCs向肿瘤相关成纤维细胞分化[J].基础医学与临床,2018,38(7):901-906.
[32]任春霞,马锦琪,吕祝武,等.IL-6通过活化STAT3/Notch信号促进癌相关成纤维细胞衰老及宫颈癌上皮细胞侵袭与放疗抵抗的机理研究[J].中国癌症杂志,2016,26(12):961-967.
[33]孙振华,赵志泓,蒋华平,等.肿瘤微环境相关因子IL-6、IL-10、CXCR7在甲状腺乳头状癌中的表达及临床意义[J].中国普通外科杂志,2017,26(5):578-582.
[34]Isobe A,Sawada K,Kinose Y,et al.Interleukin6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer[J].PLo S One,2015,10(2):e0118080.
[35]杨争艳.IL-6/STAT3/Jagged-I/Notch环路调控胃癌细胞赫赛汀获得性耐药[D].北京:中国人民解放军军事科学院,2015.
[36]夏婷,胡衡,朱群安,等.mi RNA-26b靶向IL-6/STAT3信号通路诱导肝癌细胞自噬的实验研究[J].临床肿瘤学杂志,2018,23(7):593-597.
[37]Linnskog R,Mohapatra P,Moradi F,et al.Demonstration of a WNF5A-IL-6 positive feedback loop in melanoma cells:Dual interference of this loop more effectively impairs melanoma cell invasion[J].Oncotarget,2016,7(25):37790-37802.
基本信息:
中图分类号:R730.43
引用信息:
[1]孙阳,陶雪莲,徐放,等.白细胞介素-6与肿瘤的研究进展[J].中国医学装备,2019,16(11):182-185.
基金信息:
国家自然科学基金(青年基金)(81704054)“基于JAK/STAT及PI3K/Akt/mTOR信号通路研究贞术消积汤对肝癌细胞的干预作用及其机制”;; 国家自然基金(面上项目)(81873312)“基于皮肤微生物群与Th17/Treg失衡相关性探讨发汗祛风托毒方治疗白癜风机制及病因学研究”;; 中国博士后科学基金资助项目(2014M551288)“鳖甲煎丸对肝癌细胞的抑制作用及其机制研究”;; 黑龙江省博士后资助项目(LBH-Z13205)“鳖甲煎丸诱导肝癌细胞凋亡及对JAK-STAT信号通路的影响”;; 黑龙江省自然科学基金(面上项目)(H201462)“温阳发汗法对白癜风T细胞免疫异常的作用机制研究”
2019-11-26
2019-11-26
2019-11-26